"Exposure and risk assessment of 1,3-butadiene in Japan"

Haruyuki Higashino, Kazuaki MITA , Hiroshi Yoshikado, Mistuo Iwata, Junko Nakanishi

National Institute of Advanced Industrial Science and Technology

  CHEMICO-BIOLOGICAL INTERACTIONS, vol.166  No1 pp52-62 (2007/3)

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Abstract

We assessed the risks and consequences of exposure to 1,3-butadiene on human health. A remarkable advantage of our risk assessment approach is the detailed assessment of exposure.The results suggested that the majority of the population in Japan has an excess lifetime cancer risk of less than 10-5, whereas a small number of people living close to industrial sources had a risk of greater than 10-5. The results of the present assessment also showed that 1,3-butadiene in the general environment originates primarily from automobile emissions, such that a countermeasure of reducing emissions from cars is expected to be effective at reducing the total cancer risk among Japanese.

Keywords

1,3-butadiene; Exposure assessment; Risk assessment; Human health; Japan