"Half-life of each dioxin and PCB congener in the human body" 

Isamu Ogura

National Institute of Advanced Industrial Science and Technology

24th International Symposium on Halogenated Environmental Organic Pollutants and POPs (Berlin, Germany 2004/9/9)

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Abstract

It is well known that dioxin and PCB congeners accumulate in the human body. For assessing their toxicological risk, it is important to know the half-life of each congener in the human body. 

This study summarizes the overall half-lives of congeners in humans as reported in the literature, and compares them with the half-lives due to fecal and sebum excretions, as estimated by data on the concentrations of congeners in feces and sebum in the literature. 

In addition, the overall half-lives of congeners for the general Japanese population were estimated from the reported data on dietary intakes and concentrations in the human body. 

Keywords

dioxins, PCBs, human body, risk assessment, half-life, model, coplanar PCBs