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LINK
Contact
Aomi 2-4-7, Koto-ku,
Tokyo 135-0064, JAPAN
Biomedicinal Information Research Center (BIRC)
Tel：+81-3-3599-8100
FAX：+81-3-3599-2064
mail：birc_webmaster_e@m.aist.go.jp
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Project ; Diagnosis and Prevention for Mycoplasma-linked diseases
Dr. Kazuhiro Matsuda
Dr. Koji Ichiyama
Sachie Matsuda (Technical staff)
Mycoplasma pneumoniae (M. pneumoniae) is one of the pathogen of community-acquired pneumonia.
But specific and early diagnostic method of M. pneumoniae infection has been not established.
Due to the lack of a cell wall, mycoplasmas are resistant to all beta-lactams, that include Penicillins and Cephalosporins.
And Macrorides, Tetracycrines, and New quinolones are generally effective to mycoplasmas.
We discovered M. pneumoniae specific lipid-antigens and succeeded to synthesize them.
Using these lipid-antigens, we could diagnose the M. pneumoniae infection much more specific and more sensitive than conventional methods.
Because we could quantitatively diagnose Mycoplasma infections, chronic course of the infections could be known.
We would like to reveal the relations bitween Mycoplasma infections and chronic diseases, that include asthma,
chronic obstructive pulmonary diseases (COPD), autoimmune diseases, rheumatic diseases, and cenral nervous system disorders (CNS).
Then we could also synthesize Mycoplasma fermentans (M. fermentans) specific lipid-antigens that are pathogens of rheumatoid arthritis etc.
We are developing the system of "Diagnosis and Prevention for Mycoplasma-linked diseases".
And we are trying to discover new drugs for Mycoplasma -linked diseases.
| 2009 |
Molecular Cloning ans Expression of a Novel Cholonephosphotransferase Involved in Glycerophospholipid Biosynthesus of Mycoplasma fermentans.
Curr Microbiol. 58, 535-540.
Ishida, N., Irikura, D., Matsuda, K., Sato, S.,Sone, T., Tanaka, M., Asano, K.
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Synthesis and absolute structures of Mycoplasma pneumoniae β-glyceroglycolipid antigens.
Carbohydrate Research. 344, 36-43.
Miyachi, A., Miyazaki, A., Shingu, Y., Matsuda, K., Dohi, H., Nishida, Y.
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| 2008 |
Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis.
Biochemical and Biophysical Research Communication. 369, 561-566.
Kawahito, Y., Ichinose, S., Sano, H., Tsubouchi, Y., Kohno, M., Yoswhikawa, T., Tokunaga, D.,
Hojo, T., Harawsawa, R., Nakano, T., Matsuda K.
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| 2004 |
Phosphocholine-containing glycoglycerolipids of Mycoplasma fermentans as a pathogen of rheumatoid arthritis:
Possible role of Mycoplasma fermentans GGPLs in the pathogenesis of neuroendocrine-immune abnormalities.
Recent. Res. Devel. Neurosci. 1, 15-23.
Matsuda, K.
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| 2001 |
Antigens: Lipids
encyclopedia of Life Science. vol.1, 748-755.
Matsuda, K., Saito, M., Yamamoto, N.
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| 2000 |
Monoclonal antibody against Mycoplasma fermentans-specific aminoglycoglycerolipid.
Microbiol. Immunol. 441, 695-702.
Matsuda, K, Li, J-L., Ichinose, S. Harasawa, R., Saito, M, Yamamoto, N.
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Copyright(c) 2008-2011 BIRC, National Institute of Advanced Industrial Science and Technology (AIST) . All rights reserved.
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